5th RSC/SCI Symposium on GPCRs in Medicinal Chemistry

GBP

Actelion Pharmaceuticals Ltd, Basel, Switzerland
Monday 15 September - Wednesday 17 September 2014
Organised by SCI's Fine Chemicals Group and RSC's Biological & Medicinal Chemistry Sector

Synopsis

The key role of G-protein coupled receptors (GPCRs) in human disease underpins their importance to modern medicine.
We are pleased to announce that Actelion, Switzerland will support the fifth meeting in this series on GPCR drug discovery, which will combine cutting edge medicinal chemistry with innovative structural biology and novel drug design approaches.

Additional features

Programme

Monday 15 September

08:30

Registration and refreshments

 

Session Chair: to be confirmed

09:25

Opening remarks

09:30

Title to be confirmed
Bernadette Byrne, Imperial College London, UK

10:10

Allosteric modulation of G protein-coupled receptors: alternative ways to train slippery serpent(ine)s
David Hall, GlaxoSmithKline, UK

10:50

Refreshments and exhibition

11:20

Discovery of TGR5 (GPBAR1) agonists
David Piotrowski, Pfizer, US

12:00

Progress towards novel metabotropic glutamate receptor 4 (mGlu4) positive allosteric modulators for CNS disorders
Sylvain Célanire, Addex Therapeutics, Switzerland

12:40

Lunch and exhibition

13:40

CRTh2: can residence time help?
Rick Roberts, Almirall, Spain

14:20

tmGluR5 antagonists: from discovery to clinical development
Fabrizio Gasparini, Novartis, Switzerland

15:00

CB2 agonists as novel treatments for kidney diseases
Uwe Grether, F Hoffmann-La Roche Ltd, Switzerland

15:40

Refreshments and exhibition

16:10

Evolving stable GPCRs for drug screening and structural analysis
Andreas Plückthun, ETH Zurich, Switzerland

16:50

The structural basis for ligand efficacy in the b1-Adrenoceptor
Chris Tate, MRC Laboratory of Molecular Biology, UK

17:40

Close

Tuesday 16 September

09:00

Molecular basis for the unique dissociation kinetics of macitentan - a novel endothelin receptor antagonist
John Gatfield, Actelion, Switzerland

09:40

Structure-based drug design with G protein-coupled receptors: the discovery of highly selective M1 agonists
Giles Brown, Heptares, UK

10:20

Refreshments, exhibition and posters

10:50

What lessons can we learn from 20 years of chemokine receptor drug discovery?
John Cumming, AstraZeneca, UK

11:30

From structure-based chemogenomic reflection to in silico prediction of GPCR-ligand interactions
Chris de Graaf, University of Amsterdam, The Netherlands

12:10

Lunch, exhibition and posters (Two workshops will run by Chemical Computing Group during this two-hour session)

14:10

Neuroscience
To be confirmed, Janssen, Belgium

14:50

Late breaker

15:20

Late breaker

15:50

Refreshments, exhibition and posters

16:20

Novel GPR40 agonists for the treatment of type-2 diabetes
Chafiq Hamdouchi, Lilly, US

17:00

The discovery of glucagon receptor antagonists for clinical development
Emma Parmee, Merck, US

17:40

Close

19:00

Conference dinner

Wednesday 17 September

09:00

GPCRs: application of a multivalent approach
Dan Long, Theravance, US

09:40

Identification of novel GPR81 agonist lead series for target biology evaluation
Ola Fjellström, AstraZeneca, Sweden

10:10

Refreshments

10:40

GPR81 agonists for the treatment of dyslipidaemia and atherosclerosis
Richard Davenport, Takeda, UK

11:05

Structural insights in the molecular causes of congenital stationary night blindness
Ankita Singhal, Paul Scherrer Institute, Switzerland

11:30

Crystal structures of the human adenosine A2A receptor: from agonist binding to the activation mechanism
Guillaume Lebon, CNRS, France

12:10

Close

To view the conference flyer, please click here

Organising Committee

Adrian Hall, UCB (Co-chairman)
Simon Peace, GlaxoSmithKline (Co-chairman)
Xavier Leroy, Actelion
Caroline Low, Consultant
Jon Mason, Heptares
David Miller, Takeda

Posters

Posters are invited for display throughout the meeting. Please download a template here and send a one-page abstract to the secretariat by Wednesday 30 July.

Exhibition and Sponsorship

Please contact the secretariat for details of exhibitor and sponsorship opportunities.

Delegate Fees

GB£310 . . . . . . . . .SCI / RSC Member
GB£95. . . . . . . . . . SCI / RSC Student
GB£390. . . . . . . . . Non-Member
GB£130 . . . . . . . . .Non Member Student

Bursaries and Students

Discounted rates will be offered to RSC and SCI student members and some bursaries will be available.

Venue

Actelion Pharmaceuticals Ltd
Gewerbestrasse 16
CH-4123 Allschwil
Switzerland

Website

www.maggichurchouseevents.co.uk/bmcs

For more information, please contact:

Secretariat
Maggi Churchouse
Maggi Churchouse Events, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK
T: +44 (0)1359 221004
E: maggi@maggichurchouseevents.co.uk.