Kinase 2018: towards new frontiers - 8th SCI / RSC symposium on kinase inhibitor design

GBP

Babraham Research Campus, Cambridge, UK
Monday 14 - Tuesday 15 May 2018
Organised by SCI's Fine Chemicals Group and RSC's Biological and Medicinal Chemistry Sector

Synopsis

With more than 25 FDA-approved small molecules, the field of kinase inhibition continues to attract significant investment from the drug discovery and development community. The 8th SCI / RSC symposium on kinases will encompass case studies of ongoing programmes as well as successful past programmes. A range of topics including CNS kinase inhibitors, allosteric inhibitors and non-oral delivery methods will be covered, along with views and perspectives on the future of kinase inhibitor research.

Attendees

This event is aimed at all scientists interested in furthering their knowledge of kinases. It will also have wider appeal to members of the drug discovery community eager to understand how enzyme inhibitor programmes are approached and executed across the pharmaceutical industry.

Programme

Day 1 - Monday 14 May

09.30 Registration and refreshments
   
10.00 Opening remarks
   
10.05 Keynote presentation:  Targeting PI3Ks in immunity, infection and cancer
 

Klaus Okkenhaug, University of Cambridge and Babraham Institute, UK

10.45

Discovery and development of a novel, immunosuppressive class of lipid kinase inhibitors able to prolong allogeneic organ engraftment
James Reuberson, UCB, UK

11.15

Refreshments, exhibition and posters

11.45

Discovery of GDC-0077, a highly isoform selective inhibitor of PI3Ka that promotes selective degradation of mutant-p110a
Emily Hanan, Genentech, USA
   
12.20 Roger Griffin Memorial Lecture:  Inhibitors of the mitotic kinase MPS1:  discovery of an orally bioavailable preclinical development candidate
Julian Blagg, Institute of Cancer Research, UK
   
13.00 Lunch, exhibition and posters
   
14.00 A potent and orally bioavailable ERK1/2 series identified through fragment screening which modulates the phosphorylation and catalytic activity of ERK1/2
Valerio Berdini, Astex Pharmaceuticals, UK
   
14.30 NVP-LXS196, a novel PKC inhibitor for the treatment of uveal melanoma
Julien Papillon, Novartis Institutes for Biomedical Research, USA
   
15.00 Reserved for late breaker
   

15.30

Refreshments, exhibition and posters
16.00 Flash poster presentations (session 1)
   
16.20 Identification of low clearance indole acid AMPK activators for the treatment of diabetic nephropathy
David Ebner, Pfizer, USA
   
16.55 New leads from old drugs: repurposing kinase inhibitor chemotypes for tropical diseases
Michael Pollastri, Northeastern University, USA
   
17.30 Flash poster presentations (session 2)
   
17.50 Network reception, exhibition and posters
   
19.00 Conference dinner

Day 2 - Tuesday 15 May

09.00

Strategy and tactics for the discovery of Kinase inhibitors for CNS targets. A Lundbeck perspective
Klaus Bæk Simonsen, Lundbeck

09.40 Building on the success of Osimertinib - achieving CNS exposure in oncology drug discovery
Nicola Colclough, AstraZeneca, UK
   
10.20 Refreshments, exhibition and posters
   
10.50

Chemical strategies for activating PINK1, a protein kinase mutated in Parkinson’s disease
Youcef Mehellou, Cardiff School of Pharmacy and Pharmaceutical Sciences, UK

11.30 BBB penetrating tetracyclic TRK-selective inhibitor CH7057288: additional efficacy against brain metastasis in vivo model
Toshiya Ito, Chugai, Japan
   

12.10

Interactive session
12.45 Lunch, exhibition and posters
   
13.45 Discovery of the clinical candidate AZD1390: a high quality, potent and selective inhibitor of ATM kinase with the ability to cross the blood brain barrier
Thomas Hunt, AstraZeneca, UK
   
14.25

Structural mechanisms of regulation of the PI3Ks and related kinases
Roger Williams, MRC Laboratory of Molecular Biology, UK

15.05 Closing remarks
   
15.10 Close

Organising Committee

Call for posters

A poster session will take place at the end of Day 1. A one-page abstract should be submitted to the Secretariat by Friday 30 March 2018. When submitting posters, delegates should indicate whether they would be prepared to give a single-slide summary of their poster in a formal presentation session that will take place on Day 1. For further information, please contact us by email.

Exhibition and sponsorship

An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please contact us by email. Spaces are limited and will be allocated on a first come, first served basis.

Students and Bursaries

Discounted rates are offered to SCI and RSC student members, and some student bursaries are available. Please download a bursary application form here. The deadline for bursary applications is 2 April 2018.

Venue

Cambridge Building, Babraham Research Campus
Babraham Hall
Babraham
Cambridge
CB22 3AT

Please click here for directions and a location map.

Accommodation

Accommodation options can be found here.

Coach Transport

A coach has been booked to provide transport. This is provided gratis, and you are advised to book your requirements at the time of registration, as the limited number of spaces will be allocated on a "first come, first served" basis. For more information click here.

Delegate fees

Early bird fees before Wednesday 7 February 2018

GB£269 . . . . . . . . . . . . . . . . . SCI / RSC Member
GB£140 . . . . . . . . . . . . . . . . . SCI / RSC Student Member
GB£325 . . . . . . . . . . . . . . . . . Non-Member
GB£159 . . . . . . . . . . . . . . . . . Student Non-Member

Standard fees after Wednesday 7 February 2018

GB£324 . . . . . . . . . . . . . . . . . SCI / RSC Member
GB£168 . . . . . . . . . . . . . . . . . SCI / RSC Student Member
GB£392 . . . . . . . . . . . . . . . . . Non-Member
GB£196 . . . . . . . . . . . . . . . . . Student Non-Member

Late rates for payments received from 12th April onwards. £40 Late payment fee to be added to the above standard rates.

Did you know that as an SCI member you can save on this and future event delegate fees?
Join SCI now; individual membership is only £90 pa (£75 pa direct debit). To find out more click here.

For booking terms and conditions click here.

For more information, or to book, please contact:

www.maggichurchouseevents.co.uk/bmcs

Mrs Maggi Churchouse
Maggi Churchouse Events
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