Designing Safer Medicines III

GBP

SCI, London, UK
Monday 15 October 2018
Organised by SCI's Fine Chemicals Group

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This event runs back to back with Highlights in Medicinal Chemistry III.  A discount is available for registering for both meetings.

Synopsis

There is a clear need in drug development to reduce attrition from clinical studies especially due to toxicology. It was estimated that a 5-10% improvement in the attrition rate could double the output of marketed drugs. This meeting aims to provide practical insights into some of the recent preclinical approaches and strategies which have been developed to help the chemist design safer medicines.

Attendees

This meeting is targeted at all those who are involved in the lead identification and lead optimisation processes in Drug Discovery and interested in furthering their knowledge of current and emerging approaches to designing safer Drug Candidates.

SCI Members attending this meeting are able to claim CPD points.

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Programme

09.15 Registration and refreshments
   
09.45 Opening remarks
   
09.50 The impact of safety pharmacology assays at AstraZeneca within the "5R Framework"
Dr Dean Brown, AstraZeneca, USA
   
10.30 Challenges and opportunities for predicting developmental toxicity in new active substance research projects - a crop protection perspective
Dr Richard Currie, Syngenta, UK
   
11.10 Refreshment break
   
11.40 De-risking DILI using 3D liver microtissues
Dr Paul Walker, Cyprotex, UK
   
12.20 High dimensional profiling supporting early safety screening
Dr Hinrich Göhlmann, Janssen Pharmaceutica, Belgium
   
13.00 Lunch and exhibition
   
14.10 Designing safer oral glucocorticoid receptor modulators
Dr Lena Ripa, AstraZeneca, Sweden
   
14.50 Investigation of the mechanism of toxicity of a novel immuno-oncology agent
Dr Howard Mellor, Vertex, UK
   
15.20 Refreshment break
   
15.50 Application of oral drug suitability parameters in designing safer drugs
Dr Mark Wenlock, InSilicoLynx Limited, UK
   
16.30 Data-driven drug and compound safety - using chemical and biological data to anticipate undesired effects
Dr Andreas Bender, University of Cambridge, UK
   
17.10 Closing remarks
   
17.15 Networking and refreshments

Organising Committee

Sarah Major, SCI/ Evotec
Nigel Swain, SCI/ Heptares
Al Dossetter, SCI/ Mechemica Ltd
Iain Simpson SCI/ AstraZeneca
Graham Smith, AstraZeneca

Exhibition and Sponsorship

An exhibition will take place alongside the conference during refreshment breaks for companies and related organisations who may wish to exhibit. For further information and prices, please email conferences@soci.org. Spaces are limited and will be allocated on a first come, first served basis.

Bursaries

A limited number of bursaries are being offered to SCI student members to cover their registration fee. To apply for a bursary, please send an email to conferences@soci.org with the title "Designing Safer Medicines III - bursary application" before Friday 21 September.

Venue

SCI
14/15 Belgrave Square
London
SW1X 8PS

Please click here for a location map.

Delegate Fees

Early bird fees before Monday 3 September 2018

One-Day Fee   Two-Day Fee*  
SCI Member £100 SCI Member £175
SCI Student Member £35 SCI Student Member £60
Non-Member £130 Non-Member £235

*The Two-Day Fee includes attendance at 'Designing Safer Medicines III' on Monday 15 October and 'Highlights in Medicinal Chemistry III' on Tuesday 16 October

Standard fees after Monday 3 September 2018

One-Day Fee   Two-Day Fee*  
SCI Member £115 SCI Member £205
SCI Student Member £40 SCI Student Member £70
Non-Member £150 Non-Member £270

*The Two-Day Fee includes attendance at 'Designing Safer Medicines III' on Monday 15 October and 'Highlights in Medicinal Chemistry III' on Tuesday 16 October

SCI Platinum Corporate Members receive 25% off the above rates.

Did you know that as an SCI member you can save on this and future event delegate fees?
Join SCI now; individual membership is only £90 pa (£75 pa direct debit). To find out more click here.

For booking terms and conditions click here.

For more information, please contact:

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Conference Team
T: +44 (0)20 7598 1561
E: conferences@soci.org

Sponsors

Evotec (UK) Ltd

AstraZeneca

Heptares

Vertex

Related Links

Fine Chemicals Group